The hemangioblast was first hypothesized in 1900 by Wilhelm His. Existence of the hemangioblast was first proposed in 1917 by Florence Sabin, who observed the close spacial and temporal proximity of the emergence of blood vessels and red blood cells within the yolk sac in chick embryos. In 1932, making the same observation as Sabin, Murray coined the term “hemangioblast.”
There is now emerging evidence of hemangioblasts that continue to exist in the adult as circulating stem cells in the peripheral blood that can give rise to both endothelial cells and hematopoietic cells.
Adds Ethan: “As Paul Klee once said, ‘a drawing is taking your blood cells out for a walk.’”